Tumor-specific apoptotic gene targeting overcomes radiation resistance in esophageal adenocarcinoma
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چکیده
منابع مشابه
A stapled BIM peptide overcomes apoptotic resistance in hematologic cancers.
Cancer cells subvert the natural balance between cellular life and death, achieving immortality through pathologic enforcement of survival pathways and blockade of cell death mechanisms. Pro-apoptotic BCL-2 family proteins are frequently disarmed in relapsed and refractory cancer through genetic deletion or interaction-based neutralization by overexpressed antiapoptotic proteins, resulting in r...
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متن کاملTargeting biliverdin reductase overcomes multidrug resistance in leukemia HL60 cells.
BACKGROUND/AIM Altered redox status has been reported to play a significant role in the development of multidrug resistance (MDR) in leukemia cells. Human biliverdin reductase (hBVR) has been recently identified as a major cytoprotectant; however, its role in MDR has not been yet investigated. In the present study we evaluated the possible role of hBVR in MDR development in the human HL60 leuke...
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ژورنال
عنوان ژورنال: International Journal of Radiation Oncology*Biology*Physics
سال: 2006
ISSN: 0360-3016
DOI: 10.1016/j.ijrobp.2005.11.045